Karen Elise Simpson, 67, of Florence, passed away Saturday, April 15, 2023. She was born March 10, 1956, a daughter of the late William and Irene Smith. She is survived by her children Sharon (James) Poff, Bobby Nelson, Jeff (Erika) Simpson and Krista (Benny) Rhodes; grandchildren Catlin, James Jr. and Bryan Poff, Breeanna and Sara Nelson, Jeff Jr. and Travis Simpson, Hailey Simpson and Benny Rhodes. Karen is preceded in death by her husband, Ronald Simpson. Services will be held at the convenience of the family.